Structural insights into DNA polymerase β fidelity:: hold tight if you want it right

被引：83

作者：

Beard, WA ^{[1
]}

Wilson, SH ^{[1
]}

机构：

[1] NIEHS, Struct Biol Lab, Res Triangle Pk, NC 27709 USA

来源：

CHEMISTRY & BIOLOGY | 1998年 / 5卷 / 01期

关键词：

D O I：

10.1016/S1074-5521(98)90081-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA polymerases must select and incorporate the correct deoxynucleoside 5'-triphosphate from a pool of structurally similar molecules. The structural and kinetic characterization of DNA polymerase beta indicates that this polymerase must stabilize the templating base to achieve efficient polymerization with high fidelity.

引用

页码：R7 / R13

页数：7

共 27 条

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