PTPN22 and autoimmune disease

被引：102

作者：

Siminovitch, KA ^{[1
]}

机构：

[1] Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada

来源：

NATURE GENETICS | 2004年 / 36卷 / 12期

关键词：

D O I：

10.1038/ng1204-1248

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Protein tyrosine phosphatases (PTPs) have diverse roles as negative regulators of stimulatory signaling cascades and are widely recognized as key to maintaining immune cellular homeostasis. Recent data implicating the PTP Lyp in susceptibility to four autoimmune diseases attests to the biological importance of PTP immune regulatory roles and to the etiologic relatedness of different autoimmune conditions.

引用

页码：1248 / 1249

页数：2

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