A transgenic strategy for analysis of the function of the endothelin-B-receptor

被引:2
作者
Bagnall, A [1 ]
Webb, D [1 ]
Kotelevtsev, Y [1 ]
机构
[1] Western Gen Hosp, Dept Med Sci, Edinburgh, Midlothian, Scotland
关键词
endothelin (ET); ETB receptor; knockout (KO); Cre recombinase; transgenic;
D O I
10.1097/00005344-200036001-00029
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Knockout (KO) models have provided important insights into the function of many receptors and signalling molecules. However, analysis of endothelin (ET) receptor knockouts has been complicated by the development of lethal phenotypes. In this paper, we present our strategy for examining endothclin-B-(ETB) receptor function in the context of other strategies for rescuing the lethal phenotype of ETB knockout mice.
引用
收藏
页码:S90 / S92
页数:3
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