Longevity and lineages: Toward the integrative biology of degenerative diseases in heart, muscle, and bone

被引：116

作者：

Chien, KR ^{[1
]}

Karsenty, G

机构：

[1] Univ Calif San Diego, Sch Med, Inst Mol Med, La Jolla, CA 92093 USA

[2] Baylor Coll Med, Dept Genet, Houston, TX 77030 USA

来源：

CELL | 2005年 / 120卷 / 04期

关键词：

D O I：

10.1016/j.cell.2005.02.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human aging is characterized by debilitating diseases, including heart failure, cardiac pacemaker defects, muscle wasting, and osteoporosis, in heart, skeletal muscle, and bone. Recent studies are identifying pathways for these aging-related diseases by examining how the process of aging influences tissue-specific progenitors and differentiated cell lineages in these organ systems. These advances form a foundation for new therapeutic strategies to delay the onset of aging-related disorders.

引用

页码：533 / 544

页数：12

共 83 条

[1] TSH is a negative regulator of skeletal remodeling [J].

Abe, E ;

Marians, RC ;

Yu, WQ ;

Wu, XB ;

Ando, T ;

Li, YN ;

Iqbal, J ;

Eldeiry, L ;

Rajendren, G ;

Blair, HC ;

Davies, TF ;

Zaidi, M .

CELL, 2003, 115 (02) :151-162

[2] FoxOs at the crossroads of cellular metabolism, differentiation, and transformation [J].

Accili, D ;

Arden, KC .

CELL, 2004, 117 (04) :421-426

[3] Hypothalamic Y2 receptors regulate bone formation [J].

Baldock, PA ;

Sainsbury, A ;

Couzens, M ;

Enriquez, RF ;

Thomas, GP ;

Gardiner, EM ;

Herzog, H .

JOURNAL OF CLINICAL INVESTIGATION, 2002, 109 (07) :915-921

[4] Viral mediated expression of insulin-like growth factor I blocks the aging-related loss of skeletal muscle function [J].

Barton-Davis, ER ;

Shoturma, DI ;

Musaro, A ;

Rosenthal, N ;

Sweeney, HL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15603-15607

[5]

Bernecker Oliver Y, 2003, Semin Thorac Cardiovasc Surg, V15, P268, DOI 10.1016/S1043-0679(03)70006-9

[6] Functional improvement of dystrophic muscle by myostatin blockade [J].

Bogdanovich, S ;

Krag, TOB ;

Barton, ER ;

Morris, LD ;

Whittemore, LA ;

Ahima, RS ;

Khurana, TS .

NATURE, 2002, 420 (6914) :418-421

[7] High bone density due to a mutation in LDL-receptor-related protein 5 [J].

Boyden, LM ;

Mao, JH ;

Belsky, J ;

Mitzner, L ;

Farhi, A ;

Mitnick, MA ;

Wu, DQ ;

Insogna, K ;

Lifton, RP .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (20) :1513-1521

[8] Osteoclast differentiation and activation [J].

Boyle, WJ ;

Simonet, WS ;

Lacey, DL .

NATURE, 2003, 423 (6937) :337-342

[9] Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase [J].

Brunet, A ;

Sweeney, LB ;

Sturgill, JF ;

Chua, KF ;

Greer, PL ;

Lin, YX ;

Tran, H ;

Ross, SE ;

Mostoslavsky, R ;

Cohen, HY ;

Hu, LS ;

Cheng, HL ;

Jedrychowski, MP ;

Gygi, SP ;

Sinclair, DA ;

Alt, FW ;

Greenberg, ME .

SCIENCE, 2004, 303 (5666) :2011-2015

[10] Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart [J].

Cai, CL ;

Liang, XQ ;

Shi, YQ ;

Chu, PH ;

Pfaff, SL ;

Chen, J ;

Evans, S .

DEVELOPMENTAL CELL, 2003, 5 (06) :877-889

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