Longevity and lineages: Toward the integrative biology of degenerative diseases in heart, muscle, and bone

被引：116

作者：

Chien, KR ^{[1
]}

Karsenty, G

机构：

[1] Univ Calif San Diego, Sch Med, Inst Mol Med, La Jolla, CA 92093 USA

[2] Baylor Coll Med, Dept Genet, Houston, TX 77030 USA

来源：

CELL | 2005年 / 120卷 / 04期

关键词：

D O I：

10.1016/j.cell.2005.02.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human aging is characterized by debilitating diseases, including heart failure, cardiac pacemaker defects, muscle wasting, and osteoporosis, in heart, skeletal muscle, and bone. Recent studies are identifying pathways for these aging-related diseases by examining how the process of aging influences tissue-specific progenitors and differentiated cell lineages in these organ systems. These advances form a foundation for new therapeutic strategies to delay the onset of aging-related disorders.

引用

页码：533 / 544

页数：12

共 83 条

[11] Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes [J].

Campisi, J .

EXPERIMENTAL GERONTOLOGY, 2003, 38 (1-2) :5-11

[12]

Cheng G, 1999, DEVELOPMENT, V126, P5041

[13] Converging pathways and principles in heart development and disease: CV@CSH [J].

Chien, KR ;

Olson, EN .

CELL, 2002, 110 (02) :153-162

[14] Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein [J].

Clancy, DJ ;

Gems, D ;

Harshman, LG ;

Oldham, S ;

Stocker, H ;

Hafen, E ;

Leevers, SJ ;

Partridge, L .

SCIENCE, 2001, 292 (5514) :104-106

[15]

Cooper Cyrus, 1996, P419

[16] MITOCHONDRIAL-DNA DELETIONS IN HUMAN BRAIN - REGIONAL VARIABILITY AND INCREASE WITH ADVANCED AGE [J].

CORRALDEBRINSKI, M ;

HORTON, T ;

LOTT, MT ;

SHOFFNER, JM ;

BEAL, MF ;

WALLACE, DC .

NATURE GENETICS, 1992, 2 (04) :324-329

[17] The mitochondrial death pathway and cardiac myocyte apoptosis [J].

Crow, MT ;

Mani, K ;

Nam, YJ ;

Kitsis, RN .

CIRCULATION RESEARCH, 2004, 95 (10) :957-970

[18] Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo [J].

Dacquin, R ;

Davey, RA ;

Laplace, C ;

Levasseur, G ;

Morris, HA ;

Goldring, SR ;

Gebre-Medhin, S ;

Galson, DL ;

Zajac, JD ;

Karsenty, G .

JOURNAL OF CELL BIOLOGY, 2004, 164 (04) :509-514

[19] Targeted disruption of the α1,3-galactosyltransferase gene in cloned pigs [J].

Dai, YF ;

Vaught, TD ;

Boone, J ;

Chen, SH ;

Phelps, CJ ;

Ball, S ;

Monahan, JA ;

Jobst, PM ;

McCreath, KJ ;

Lamborn, AE ;

Cowell-Lucero, JL ;

Wells, KD ;

Colman, A ;

Polejaeva, IA ;

Ayares, DL .

NATURE BIOTECHNOLOGY, 2002, 20 (03) :251-255

[20] Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity [J].

Daitoku, H ;

Hatta, M ;

Matsuzaki, H ;

Aratani, S ;

Ohshima, T ;

Miyagishi, M ;

Nakajima, T ;

Fukamizu, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (27) :10042-10047

← 1 2 3 4 5 6 7 8 9 →