Dysinosins B-D, inhibitors of factor VIIa and thrombin from the Australian sponge Lamellodysidea chlorea

被引：54

作者：

Carroll, AR ^{[1
]}

Buchanan, MS ^{[1
]}

Edser, A ^{[1
]}

Hyde, E ^{[1
]}

Simpson, M ^{[1
]}

Quinn, RJ ^{[1
]}

机构：

[1] Griffith Univ, Eskitis Inst, Brisbane, Qld 4111, Australia

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 08期

关键词：

D O I：

10.1021/np049968p

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new marine natural products, dysinosins B-D (1-3), were isolated from the sponge Lamellodysidea chlorea and their structures determined by 1D and 2D NMR spectroscopy. These compounds are inhibitors of the blood coagulation cascade serine proteases factor VIIa and thrombin. These analogues, dysinosins B-D (1-3), allowed identification of two structural motifs within the structures that contribute to binding to the proteases, factor VIIa and thrombin.

引用

页码：1291 / 1294

页数：4

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