Use of N-N bond stereodynamics in ring-closing metathesis to form medium-sized rings and macrocycles

被引：49

作者：

Kim, YJ ^{[1
]}

Lee, D ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 23期

关键词：

D O I：

10.1021/ol048136f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A unique strategy based on double ring-closing metathesis for the formation of a 14-membered macrocyclic enamide has been developed. This strategy hinges upon the well-known stereodynamic and conformational behavior of N-substituted diacylhydrazines, which promotes an effective ring-closing metathesis of hydrazine-derived dienes and enynes to form 8- to 14-membered rings.

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收藏

页码：4351 / 4353

页数：3

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