Regulation by adrenocorticotropic hormone and arachidonate of the expression of acyl-CoA synthetase 4, an arachidonate-preferring enzyme expressed in steroidogenic tissues

被引：15

作者：

Cho, YY ^{[1
]}

Kang, MJ ^{[1
]}

Ogawa, S ^{[1
]}

Yamashita, Y ^{[1
]}

Fujino, T ^{[1
]}

Yamamoto, TT ^{[1
]}

机构：

[1] Tohoku Univ, Ctr Gene Res, Aoba Ku, Sendai, Miyagi 9818555, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2000年 / 274卷 / 03期

基金：

日本学术振兴会;

关键词：

ACTH; acyl-CoA synthetase; arachidonate; steroidogenesis;

D O I：

10.1006/bbrc.2000.3207

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acyl-CoA synthetase 4 (ACS4) is an arachidonate-preferring enzyme abundant in steroidogenic tissues. We demonstrate that ACS4 expression in steroidogenic tissues in vivo is induced by adrenocorticotropic hormone (ACTH) and suppressed by glucocorticoid. ACTH also induced ACS4 protein but not its mRNA in Y1 adrenocortical tumor cells, whereas both ACS4 mRNA and protein were increased by dibutyryl cAMP (db-cAMP) and forskolin. Furthermore, the levels of ACS4 mRNA and protein in Y1 cells were induced by arachidonate. These data suggest that ACS4 expression in steroidogenic cells is regulated in coordination with induced steroidogenesis and arachidonate released by cholesterol ester hydrolase, (C) 2000 Academic Press.

引用

页码：741 / 745

页数：5

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