Nickel-catalyzed coupling reaction of sterically congested cis bromides and lithium alkenylborates

被引：37

作者：

Kobayashi, Y ^{[1
]}

Nakayama, Y ^{[1
]}

Mizojiri, R ^{[1
]}

机构：

[1] Tokyo Inst Technol, Dept Biomol Engn, Midori Ku, Yokohama, Kanagawa 226, Japan

来源：

TETRAHEDRON | 1998年 / 54卷 / 07期

关键词：

D O I：

10.1016/S0040-4020(97)10206-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Lithium alkenyl berates of general structure 5 (RT = alkenyl) couple with cis bromides 1 at room temperature overnight in the presence of NiCl2(PPh3)(2) as a catalyst to furnish dienes of general structure 3 with retention of the olefin geometries present in both coupling partners. By using this reaction, cis,trans dienes 3 (R = TBDMS, TES, TBDPS; R-1 = n-C5H11, c-C6H11; R-2 = H; R-3 = n-C5H11, Ph) and cis,cis diene 3 (R = TBDMS; R-1 = R-2 = n-C5H11; R-3 = H) are synthesized in good yields. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：1053 / 1062

页数：10

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