Bile acid regulation of hepatic physiology - IV. Bile acids and death receptors

被引：93

作者：

Higuchi, H ^{[1
]}

Gores, GJ ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Mayo Med Sch, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2003年 / 284卷 / 05期

关键词：

Fas; tumor necrosis factor-associated apoptosis-inducing ligand; Bid;

D O I：

10.1152/ajpgi.00491.2002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Toxic bile acids facilitate Fas and tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) death-receptor oligomerization and activation. Bile acid modulation of death-receptor signaling is multifactorial and includes trafficking of Fas to the cell surface, enhancing TRAIL-R2/DR5 expression, and suppression of function of cFLIP, an antiapoptotic protein modulating death-receptor function. Because bile acid-associated death receptor-mediated apoptosis is a common mechanism for cholestatic hepatocyte injury, inhibition of death receptors and their cascades may prove useful in attenuating liver injury during cholestasis.

引用

页码：G734 / G738

页数：5

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