Bile acid regulation of hepatic physiology - IV. Bile acids and death receptors

被引：93

作者：

Higuchi, H ^{[1
]}

Gores, GJ ^{[1
]}

机构：

[1] Mayo Clin & Mayo Fdn, Mayo Med Sch, Div Gastroenterol & Hepatol, Rochester, MN 55905 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 2003年 / 284卷 / 05期

关键词：

Fas; tumor necrosis factor-associated apoptosis-inducing ligand; Bid;

D O I：

10.1152/ajpgi.00491.2002

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Toxic bile acids facilitate Fas and tumor necrosis factor-associated apoptosis-inducing ligand (TRAIL) death-receptor oligomerization and activation. Bile acid modulation of death-receptor signaling is multifactorial and includes trafficking of Fas to the cell surface, enhancing TRAIL-R2/DR5 expression, and suppression of function of cFLIP, an antiapoptotic protein modulating death-receptor function. Because bile acid-associated death receptor-mediated apoptosis is a common mechanism for cholestatic hepatocyte injury, inhibition of death receptors and their cascades may prove useful in attenuating liver injury during cholestasis.

引用

页码：G734 / G738

页数：5

共 25 条

[11] The bile acid glycochenodeoxycholate induces TRAIL-receptor 2/DR5 expression and apoptosis [J].

Higuchi, H ;

Bronk, SF ;

Takikawa, Y ;

Werneburg, N ;

Takimoto, R ;

El-Deiry, W ;

Gores, GJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) :38610-38618

[12]

Higuchi H, 2001, J PHARMACOL EXP THER, V299, P866

[13] Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C [J].

Jones, BA ;

Rao, YP ;

Stravitz, RT ;

Gores, GJ .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 1997, 272 (05) :G1109-G1115

[14] TOXICITY OF BILE-ACIDS ON THE ELECTRON-TRANSPORT CHAIN OF ISOLATED RAT-LIVER MITOCHONDRIA [J].

KRAHENBUHL, S ;

TALOS, C ;

FISCHER, S ;

REICHEN, J .

HEPATOLOGY, 1994, 19 (02) :471-479

[15] Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas [J].

Miyoshi, H ;

Rust, C ;

Roberts, PJ ;

Burgart, LJ ;

Gores, GJ .

GASTROENTEROLOGY, 1999, 117 (03) :669-677

[16]

Nitta T, 2002, HEPATOLOGY, V36, p300A

[17] Deoxycholic acid (DCA) causes ligand-independent activation of epidermal growth factor receptor (EGFR) and FAS receptor in primary hepatocytes: Inhibition of EGFR/mitogen-activated protein kinase-signaling module enhances DCA-induced apoptosis [J].

Qiao, L ;

Studer, E ;

Leach, K ;

McKinstry, R ;

Gupta, S ;

Decker, R ;

Kukreja, R ;

Valerie, K ;

Nagarkatti, P ;

El Deiry, W ;

Molkentin, J ;

Schmidt-Ullrich, R ;

Fisher, PB ;

Grant, S ;

Hylemon, PB ;

Dent, P .

MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (09) :2629-2645

[18] Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production [J].

Rodrigues, CMP ;

Fan, GS ;

Wong, PY ;

Kren, BT ;

Steer, CJ .

MOLECULAR MEDICINE, 1998, 4 (03) :165-178

[19] Two CD95 (APO-1/Fas) signaling pathways [J].

Scaffidi, C ;

Fulda, S ;

Srinivasan, A ;

Friesen, C ;

Li, F ;

Tomaselli, KJ ;

Debatin, KM ;

Krammer, PH ;

Peter, ME .

EMBO JOURNAL, 1998, 17 (06) :1675-1687

[20] Bile salts mediate hepatocyte apoptosis by increasing cell surface trafficking of Fas [J].

Sodeman, T ;

Bronk, SF ;

Roberts, PJ ;

Miyoshi, H ;

Gores, GJ .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2000, 278 (06) :G992-G999

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