Linear free energy substituent effect on flavin redox chemistry

被引：75

作者：

Hasford, JJ ^{[1
]}

Rizzo, CJ ^{[1
]}

机构：

[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37235 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 1998年 / 120卷 / 10期

关键词：

D O I：

10.1021/ja972992n

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A systematic study on the effect of various substituents at the 7- and/or 8-position on the redox properties of isoalloxazines (flavins) is reported. The redox properties of these flavin derivatives were studied by cyclic voltammetry in 100 mM, pH 7.4 HEPES and 200 mM, pH 10 berate buffers. The magnitude and direction of the effect was dependent on the nature and location of the substituent. The redox potentials of the substituted flavins were correlated with the Hammett sigma value of the substituents.

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页码：2251 / 2255

页数：5

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