T-cell co-stimulatory molecules: novel targets for the treatment of allergic airway disease

被引：14

作者：

Beier, K. C. ^{[1
]}

Kallinich, T. ^{[1
]}

Hamelmann, E. ^{[1
]}

机构：

[1] Univ Med Berlin, Charite, Dept Paediat Pneumol & Immunol, D-13353 Berlin, Germany

来源：

EUROPEAN RESPIRATORY JOURNAL | 2007年 / 30卷 / 02期

关键词：

allergic airway disease; asthma; co-stimulation; T-cells; therapeutic targets;

D O I：

10.1183/09031936.00094406

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The first two articles in this series discussed the fundamental concept of T-cell co-stimulation as a key event in the induction of any immune response, in addition to reviewing the current data on the role of co-stimulatory molecules for the induction and progression of allergic airway diseases. Based on these considerations, this final edition will delineate and discuss novel strategies for the prevention and/or therapy of allergic diseases based upon the modulation of costimulation.

引用

页码：383 / 390

页数：8

共 63 条

[1] Blockade of T lymphocyte costimulation with cytotoxic T lymphocyte-associated antigen 4-immunoglobulin (CTLA4Ig) reverses the cellular pathology of psoriatic plaques, including the activation of keratinocytes, dendritic cells, and endothelial cells [J].

Abrams, JR ;

Kelley, SL ;

Hayes, E ;

Kikuchi, T ;

Brown, MJ ;

Kang, SW ;

Lebwohl, MG ;

Guzzo, CA ;

Jegasothy, BV ;

Linsley, PS ;

Krueger, JG .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (05) :681-693

[2]

Akbari O, 2002, NAT MED, V8, P1024, DOI 10.1038/nm745

[3] Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis [J].

Akiba, H ;

Miyahira, Y ;

Atsuta, M ;

Takeda, K ;

Nohara, C ;

Futagawa, T ;

Matsuda, H ;

Aoki, T ;

Yagita, H ;

Okumura, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (02) :375-380

[4]

Arestides RSS, 2002, EUR J IMMUNOL, V32, P2874, DOI 10.1002/1521-4141(2002010)32:10<2874::AID-IMMU2874>3.0.CO

[5]

2-4

[6] IDENTIFICATION OF ACTIVATED LYMPHOCYTES-T AND EOSINOPHILS IN BRONCHIAL BIOPSIES IN STABLE ATOPIC ASTHMA [J].

AZZAWI, M ;

BRADLEY, B ;

JEFFERY, PK ;

FREW, AJ ;

WARDLAW, AJ ;

KNOWLES, G ;

ASSOUFI, B ;

COLLINS, JV ;

DURHAM, S ;

KAY, AB .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1990, 142 (06) :1407-1413

[7] Can guideline-defined asthma control be achieved? The gaining optimal asthma control study [J].

Bateman, ED ;

Boushey, HA ;

Bousquet, J ;

Busse, WW ;

Clark, TJH ;

Pauwels, RA ;

Pedersen, SE .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 170 (08) :836-844

[8] Master switches of T-cell activation and differentiation [J].

Beier, K. C. ;

Kallinich, T. ;

Hamelmann, E. .

EUROPEAN RESPIRATORY JOURNAL, 2007, 29 (04) :804-812

[9] CTLA41g: Bridging the basic immunology with clinical application [J].

Bluestone, JA ;

St Clair, EW ;

Turka, LA .

IMMUNITY, 2006, 24 (03) :233-238

[10] The CD28-related molecule ICOS is required for effective T cell-dependent immune responses [J].

Coyle, AJ ;

Lehar, S ;

Lloyd, C ;

Tian, J ;

Delaney, T ;

Manning, S ;

Nguyen, T ;

Burwell, T ;

Schneider, H ;

Gonzalo, JA ;

Gosselin, M ;

Owen, LR ;

Rudd, CE ;

Gutierrez-Ramos, JC .

IMMUNITY, 2000, 13 (01) :95-105

← 1 2 3 4 5 6 7 →