学术探索
学术期刊
文章热点
数据分析
智能智评

The neuroprotective role of melatonin in neurological disorders

被引：168
作者：
Alghamdi, B. S. [1 ,2 ]
机构：
[1] King Abdulaziz Univ, Fac Med, Dept Physiol, Jeddah, Saudi Arabia
[2] King Abdulaziz Univ, Fac Med, Neurosci Unit, Jeddah, Saudi Arabia
来源：
JOURNAL OF NEUROSCIENCE RESEARCH | 2018年 / 96卷 / 07期
关键词：
melatonin; ischemia; alzheimer; parkinson; MILD COGNITIVE IMPAIRMENT; AMYLOID PRECURSOR PROTEIN; FOCAL CEREBRAL-ISCHEMIA; CENTRAL-NERVOUS-SYSTEM; BLOOD-BRAIN-BARRIER; FAMILIAL ALZHEIMERS-DISEASE; OXIDATIVE STRESS HYPOTHESIS; MAMMALIAN PINEAL-GLAND; PARKINSONS-DISEASE; CEREBROSPINAL-FLUID;
D O I：
10.1002/jnr.24220
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Melatonin is a neurohormone secreted from the pineal gland and has a wide-ranging regulatory and neuroprotective role. It has been reported that melatonin level is disturbed in some neurological conditions such as stroke, Alzheimer's disease, and Parkinson's disease, which indicates its involvement in the pathophysiology of these diseases. Its properties qualify it to be a promising potential therapeutic neuroprotective agent, with no side effects, for some neurological disorders. This review discusses and localizes the effect of melatonin in the pathophysiology of some diseases.
引用
收藏
页码：1136 / 1149
页数：14
相关论文
共 200 条
  • [1] Acuna-Castroviejo Dario, 1997, Life Sciences, V60, pPL23
  • [2] Adi N, 2010, MED SCI MONITOR, V16, pBR61
  • [3] Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3 pathway in the mouse hippocampus
    Ali, Tahir
    Kim, Myeong Ok
    [J]. JOURNAL OF PINEAL RESEARCH, 2015, 59 (01) : 47 - 59
  • [4] Melatonin Preserves Blood-Brain Barrier Integrity and Permeability via Matrix Metalloproteinase-9 Inhibition
    Alluri, Himakarnika
    Wilson, Rickesha L.
    Shaji, Chinchusha Anasooya
    Wiggins-Dohlvik, Katie
    Patel, Savan
    Liu, Yang
    Peng, Xu
    Beeram, Madhava R.
    Davis, Matthew L.
    Huang, Jason H.
    Tharakan, Binu
    [J]. PLOS ONE, 2016, 11 (05):
  • [5] Alvarez A, 1998, J NEUROSCI, V18, P3213
  • [6] Melatonin use for neuroprotection in perinatal asphyxia: a randomized controlled pilot study
    Aly, H.
    Elmandy, H.
    El-Dib, M.
    Rowisha, M.
    Awny, M.
    El-Gohary, T.
    Elbatcht, M.
    Hamisa, M.
    El-Mashad, A-R
    [J]. JOURNAL OF PERINATOLOGY, 2015, 35 (03) : 186 - 191
  • [7] Protective effect of melatonin in a chronic experimental model of Parkinson's disease
    Antolín, I
    Mayo, JC
    Sainz, RM
    del Brío, MD
    Herrera, F
    Martín, V
    Rodríguez, C
    [J]. BRAIN RESEARCH, 2002, 943 (02) : 163 - 173
  • [8] IMMUNOASSAY OF 6-HYDROXYMELATONIN SULFATE IN HUMAN-PLASMA AND URINE - ABOLITION OF THE URINARY 24-HOUR RHYTHM WITH ATENOLOL
    ARENDT, J
    BOJKOWSKI, C
    FRANEY, C
    WRIGHT, J
    MARKS, V
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1985, 60 (06) : 1166 - 1173
  • [9] Molecular mechanisms of calcium-dependent neurodegeneration in excitotoxicity
    Arundine, M
    Tymianski, M
    [J]. CELL CALCIUM, 2003, 34 (4-5) : 325 - 337
  • [10] Baldeiras I, 2008, J ALZHEIMERS DIS, V15, P117
12345678910