The neuroprotective role of melatonin in neurological disorders

被引：168

作者：

Alghamdi, B. S. ^{[1
,2
]}

机构：

[1] King Abdulaziz Univ, Fac Med, Dept Physiol, Jeddah, Saudi Arabia

[2] King Abdulaziz Univ, Fac Med, Neurosci Unit, Jeddah, Saudi Arabia

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2018年 / 96卷 / 07期

关键词：

melatonin; ischemia; alzheimer; parkinson; MILD COGNITIVE IMPAIRMENT; AMYLOID PRECURSOR PROTEIN; FOCAL CEREBRAL-ISCHEMIA; CENTRAL-NERVOUS-SYSTEM; BLOOD-BRAIN-BARRIER; FAMILIAL ALZHEIMERS-DISEASE; OXIDATIVE STRESS HYPOTHESIS; MAMMALIAN PINEAL-GLAND; PARKINSONS-DISEASE; CEREBROSPINAL-FLUID;

D O I：

10.1002/jnr.24220

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Melatonin is a neurohormone secreted from the pineal gland and has a wide-ranging regulatory and neuroprotective role. It has been reported that melatonin level is disturbed in some neurological conditions such as stroke, Alzheimer's disease, and Parkinson's disease, which indicates its involvement in the pathophysiology of these diseases. Its properties qualify it to be a promising potential therapeutic neuroprotective agent, with no side effects, for some neurological disorders. This review discusses and localizes the effect of melatonin in the pathophysiology of some diseases.

引用

页码：1136 / 1149

页数：14

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