Mitotic functions of kinesin-5

被引：131

作者：

Ferenz, Nick P. ^{[1
]}

Gable, Alyssa ^{[1
]}

Wadsworth, Pat ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Biol, Amherst, MA 01003 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2010年 / 21卷 / 03期

关键词：

Eg5; Mitosis; Spindle; Kinesin; Dynein; POLEWARD MICROTUBULE FLUX; SMALL-MOLECULE INHIBITOR; EGG EXTRACT SPINDLES; CROSS-LINKS MICROTUBULES; CYTOPLASMIC DYNEIN; KINETOCHORE MICROTUBULES; SACCHAROMYCES-CEREVISIAE; ASPERGILLUS-NIDULANS; DROSOPHILA EMBRYOS; MEIOTIC SPINDLES;

D O I：

10.1016/j.semcdb.2010.01.019

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In all eukaryotic cells, molecular motor proteins play essential roles in spindle assembly and function. The homotetrameric kinesin-5 motors in particular generate outward forces that establish and maintain spindle bipolarity and contribute to microtubule flux. Cell-cycle dependent phosphorylation of kinesin-5 motors regulates their localization to the mitotic spindle. Analysis of live cells further shows that kinesin-5 motors are highly dynamic in the spindle. Understanding the interactions of kinesin-5 motors with microtubules and other spindle proteins is likely to broaden the documented roles of kinesin-5 motors during cell division. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：255 / 259

页数：5