Computational enzymology

被引：33

作者：

Bruice, TC ^{[1
]}

Kahn, K ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 05期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S1367-5931(00)00129-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent advances in computational methods and the availability of fast, affordable computers have made the modeling of enzymatic reactions practical. The remaining challenges include achieving the accuracy level at which thermodynamic parameters and kinetic constants for different substrates, mutant enzymes, or in the presence of allosteric effecters can be predicted quantitatively.

引用

页码：540 / 544

页数：5

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