AML1 mutation and its coexistence with different transcription factor gene families in de novo acute myeloid leukemia: redundancy or synergism

被引：12

作者：

Auewarakul, Chirayu U. ^{[1
,3
]}

Leecharendkeat, Amporn ^{[2
,3
]}

Tocharoentanaphol, Chintana ^{[4
]}

Promsuwicha, Orathai ^{[1
,3
]}

Sritana, Narongrit ^{[4
]}

Thongnoppakhun, Wanna ^{[5
]}

机构：

[1] Mahidol Univ, Dept Med, Bangkok, Thailand

[2] Mahidol Univ, Dept Immunol, Bangkok, Thailand

[3] Mahidol Univ, Fac Med, Siriraj Hosp, Bangkok, Thailand

[4] Chulabhorn Res Inst, Chulabhorn Canc Ctr, Bangkok, Thailand

[5] Mahidol Univ, Siriraj Hosp, Fac Med, Off Res & Dev, Bangkok, Thailand

来源：

HAEMATOLOGICA | 2007年 / 92卷 / 06期

关键词：

acute myeloid leukemia; transcription factor; AML1; mutation; leukemogenesis; cooperative events;

D O I：

10.3324/haematol.10914

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

AML1 mutations were identified in 6.3% of AML patients with chromosomal translocations involving CBF, PML-RAR alpha, HOX, or ETS transcription factor (TF) gene families. Rare chromosomal abnormalities, t(16;21) and t(7; 11), were also found. This study represents the first series to demonstrate the coexistence of known and novel AML1 mutations with different TF gene mutations. Although the occurrence of two TF gene mutations may appear unnecessary, the possible synergistic mechanism between different TF gene families cannot be excluded and needs to be further explored.

引用

页码：861 / 862

页数：2