Biosynthesis: Is it time to go retro?

被引：35

作者：

Bachmann, Brian O. ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37203 USA

[2] Vanderbilt Univ, Vanderbilt Inst Chem Biol, Nashville, TN USA

来源：

NATURE CHEMICAL BIOLOGY | 2010年 / 6卷 / 06期

关键词：

PATHWAYS; ACID;

D O I：

10.1038/nchembio.377

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Artificial biosynthetic pathways are typically assembled and optimized progressively, from earlier to later steps. This commentary highlights the potential of an alternate regressive method for biochemical pathway design and generation, inspired by the retro-evolution hypothesis and the concept of retrosynthesis. In addition to being a pathway design tool, 'bioretrosynthesis' has potential as a construction and optimization methodology.

引用

页码：390 / 393

页数：4

共 18 条

[1] Chemical synthesis using synthetic biology [J].

Carothers, James M. ;

Goler, Jonathan A. ;

Keasling, Jay D. .

CURRENT OPINION IN BIOTECHNOLOGY, 2009, 20 (04) :498-503

[2]

CHENG XM, 1995, LOGIC CHEM SYNTHESIS

[3] Prediction of novel synthetic pathways for the production of desired chemicals [J].

Cho, Ayoun ;

Yun, Hongseok ;

Park, Jin Hwan ;

Lee, Sang Yup ;

Park, Sunwon .

BMC SYSTEMS BIOLOGY, 2010, 4

[4] THE LOGIC OF CHEMICAL SYNTHESIS - MULTISTEP SYNTHESIS OF COMPLEX CARBOGENIC MOLECULES [J].

COREY, EJ .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1991, 30 (05) :455-465

[5] ON THE EVOLUTION OF BIOCHEMICAL SYNTHESES [J].

HOROWITZ, NH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1945, 31 (06) :153-157

[6] Biosynthesis of L-p-hydroxyphenylglycine, a non-proteinogenic amino acid constituent of peptide antibiotics [J].

Hubbard, BK ;

Thomas, MG ;

Walsh, CT .

CHEMISTRY & BIOLOGY, 2000, 7 (12) :931-942

[7] ENZYME RECRUITMENT IN EVOLUTION OF NEW FUNCTION [J].

JENSEN, RA .

ANNUAL REVIEW OF MICROBIOLOGY, 1976, 30 :409-425

[8] The Miller volcanic spark discharge experiment [J].

Johnson, Adam P. ;

Cleaves, H. James ;

Dworkin, Jason P. ;

Glavin, Daniel P. ;

Lazcano, Antonio ;

Bada, Jeffrey L. .

SCIENCE, 2008, 322 (5900) :404-404

[9]

Larock R.C., 1989, Comprehensive Organic Transformations: A Guide to Functional Group Preparations

[10] Benzene-free synthesis of catechol: Interfacing microbial and chemical catalysis [J].

Li, WS ;

Xie, DM ;

Frost, JW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (09) :2874-2882

← 1 2 →