Simultaneous determination of valsartan and hydrochlorothiazide in tablets by high-performance liquid chromatography

被引：36

作者：

Carlucci, G ^{[1
]}

Di Carlo, V ^{[1
]}

Mazzeo, P ^{[1
]}

机构：

[1] Univ Aquila, Dipartimento Chim Ingn Chim & Mat, I-67010 Coppito, LAquila, Italy

来源：

ANALYTICAL LETTERS | 2000年 / 33卷 / 12期

关键词：

HPLC; valsartan; hydrochlorothiazide; simultaneous determination;

D O I：

10.1080/00032710008543204

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A method for the simultaneous determination of valsartan and hydrochlorothiazide in tablets is described. The procedure, based on the use of reversed-phase high-performance liquid chromatography, is linear in the concentration range 5.0-10.0 mu g ml(-1) for valsartan and 0.5-2.0 mu g ml(-1) for hydrochlorothiazide, is simple and rapid and allows accurate and precise results. The limit of detection was 1.0 mu g ml(-1) for valsartan and 0.05 mu g ml(-1) for hydrochlorothiazide.

引用

页码：2491 / 2500

页数：10

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