Synthesis of polyketides via diastereloselective acetalization

被引：10

作者：

Shepherd, JN ^{[1
]}

Myles, DC

机构：

[1] Gonzaga Univ, Dept Chem, Spokane, WA 99258 USA

[2] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA

[3] Kosan Biosci, Hayward, CA 94545 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 07期

关键词：

D O I：

10.1021/ol027538p

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] Diastereoselective acetalization of pseudo-C-2-symmetric 1,3,5-triol systems is a general strategy for the rapid generation of polyketides. The oxidative acetalization reaction shown above was studied under both kinetic and thermodynamic conditions, using synthetic 1,3,5-triol units. In addition, all possible stereochernical variants of a 1,3,5-triol system were prepared from the corresponding acetal to expand the synthetic versatility of this method.

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页码：1027 / 1030

页数：4

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