Homeostasis of αβ TCR+ T cells

被引：219

作者：

Marrack, P ^{[1
]}

Bender, J

Hildeman, D

Jordan, M

Mitchell, T

Murakami, M

Sakamoto, A

Schaefer, BC

Swanson, B

Kappler, J

机构：

[1] Natl Jewish Med & Res Ctr, Howard Hughes Med Inst, Denver, CO 80206 USA

[2] Natl Jewish Med & Res Ctr, Dept Med, Denver, CO 80206 USA

[3] Univ Colorado, Hlth Sci Ctr, Dept Immunol, Denver, CO 80206 USA

[4] Univ Colorado, Hlth Sci Ctr, Dept Biochem & Mol Biol, Denver, CO 80206 USA

[5] Univ Colorado, Hlth Sci Ctr, Dept Med, Denver, CO 80206 USA

[6] Univ Colorado, Hlth Sci Ctr, Dept Pediat, Denver, CO 80206 USA

[7] Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80206 USA

来源：

NATURE IMMUNOLOGY | 2000年 / 1卷 / 02期

基金：

日本学术振兴会;

关键词：

D O I：

10.1038/77778

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Cytokines contribute to T cell homeostasis at all stages of T cell existence. However, the particular cytokine involved varies as T cells progress from a naive through an activated to a memory state. In many cases the important cytokines are members of the interleukin 2 subfamily of the short-chain type I cytokines. A case is made for the idea that the evolutionary divergence of the short-chain family allowed for concurrent divergence in leukocytes.

引用

页码：107 / 111

页数：5