Immunotoxin Complementation of HAART to Deplete Persisting HIV-Infected Cell Reservoirs

被引：43

作者：

Berger, Edward A. ^{[1
]}

Pastan, Ira ^{[2
]}

机构：

[1] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA

[2] NCI, Mol Biol Lab, NIH, Bethesda, MD 20892 USA

来源：

PLOS PATHOGENS | 2010年 / 6卷 / 06期

关键词：

HUMAN-IMMUNODEFICIENCY-VIRUS; ACTIVE ANTIRETROVIRAL THERAPY; EXOTOXIN HYBRID PROTEIN; CD4(+) T-CELLS; REVERSE-TRANSCRIPTASE INHIBITORS; CD4-PSEUDOMONAS EXOTOXIN; IN-VITRO; ENVELOPE GLYCOPROTEINS; PSEUDOMONAS EXOTOXIN; FUTURE-DIRECTIONS;

D O I：

10.1371/journal.ppat.1000803

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

[No abstract available]

引用

页数：6

共 68 条

[1]

Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for Antiretroviral therapy [J].

Ambrose, Zandrea ;

Palmer, Sarah ;

Boltz, Valerie F. ;

Kearney, Mary ;

Larsen, Kay ;

Polacino, Patricia ;

Flanary, Leon ;

Oswald, Kelli ;

Piatak, Michael, Jr. ;

Smedley, Jerem ;

Shao, Wei ;

Bischofberger, Norbert ;

Maldarelli, Frank ;

Kimata, Jason T. ;

Mellors, John W. ;

Hu, Shiu-Lok ;

Coffin, John M. ;

Lifson, Jeffrey D. ;

KewalRamani, Vineet N. .

JOURNAL OF VIROLOGY, 2007, 81 (22) :12145-12155

[2]

ELIMINATION OF INFECTIOUS HUMAN-IMMUNODEFICIENCY-VIRUS FROM HUMAN T-CELL CULTURES BY SYNERGISTIC ACTION OF CD4-PSEUDOMONAS EXOTOXIN AND REVERSE-TRANSCRIPTASE INHIBITORS [J].

ASHORN, P ;

MOSS, B ;

WEINSTEIN, JN ;

CHAUDHARY, VK ;

FITZGERALD, DJ ;

PASTAN, I ;

BERGER, EA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (22) :8889-8893

[3]

ANTI-HIV ACTIVITY OF CD4-PSEUDOMONAS EXOTOXIN ON INFECTED PRIMARY HUMAN-LYMPHOCYTES AND MONOCYTE MACROPHAGES [J].

ASHORN, P ;

ENGLUND, G ;

MARTIN, MA ;

MOSS, B ;

BERGER, EA .

JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (04) :703-709

[4]

ASHORN P, 1992, J ACQ IMMUN DEF SYND, V5, P70

[5]

A RECOMBINANT DIPHTHERIA-TOXIN RELATED HUMAN CD4 FUSION PROTEIN SPECIFICALLY KILLS HIV INFECTED-CELLS WHICH EXPRESS GP120 BUT SELECTS FUSION TOXIN RESISTANT CELLS WHICH CARRY HIV [J].

AULLO, P ;

ALCAMI, J ;

POPOFF, MR ;

KLATZMANN, DR ;

MURPHY, JR ;

BOQUET, P .

EMBO JOURNAL, 1992, 11 (02) :575-583

[6]

Residual human immunodeficiency virus type 1 viremia in some patients on Antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells [J].

Bailey, JR ;

Sedaghat, AR ;

Kieffer, T ;

Brennan, T ;

Lee, PK ;

Wind-Rotolo, M ;

Haggerty, CM ;

Kamireddi, AR ;

Liu, Y ;

Lee, J ;

Persaud, D ;

Gallant, JE ;

Cofrancesco, J ;

Quinn, TC ;

Wilke, CO ;

Ray, SC ;

Siliciano, JD ;

Nettles, RE ;

Siliciano, RF .

JOURNAL OF VIROLOGY, 2006, 80 (13) :6441-6457

[7]

IN-VITRO EVOLUTION OF A NEUTRALIZING HUMAN-ANTIBODY TO HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 TO ENHANCE AFFINITY AND BROADEN STRAIN CROSS-REACTIVITY [J].

BARBAS, CF ;

HU, D ;

DUNLOP, N ;

SAWYER, L ;

CABABA, D ;

HENDRY, RM ;

NARA, PL ;

BURTON, DR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :3809-3813

[8]

Specific killing of HIV-infected lymphocytes by a recombinant immunotoxin directed against the HIV-1 envelope glycoprotein [J].

Bera, TK ;

Kennedy, PE ;

Berger, EA ;

Barbas, CF ;

Pastan, I .

MOLECULAR MEDICINE, 1998, 4 (06) :384-391

[9]

RECOMBINANT CD4-PSEUDOMONAS EXOTOXIN HYBRID PROTEIN DISPLAYS HIV-SPECIFIC CYTOTOXICITY WITHOUT AFFECTING MHC CLASS-II-DEPENDENT FUNCTIONS [J].

BERGER, EA ;

CHAUDHARY, VK ;

CLOUSE, KA ;

JARAQUEMADA, D ;

NICHOLAS, JA ;

RUBINO, KL ;

FITZGERALD, DJ ;

PASTAN, I ;

MOSS, B .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 1990, 6 (06) :795-804

[10]

Reconsidering targeted toxins to eliminate HIV infection: You gotta have HAART [J].

Berger, EA ;

Moss, B ;

Pastan, I .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (20) :11511-11513

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