Moderate coffee consumption increases plasma glutathione but not homocysteine in healthy subjects

被引:67
作者
Esposito, F [1 ]
Morisco, F [1 ]
Verde, V [1 ]
Ritieni, A [1 ]
Alezio, A [1 ]
Caporaso, N [1 ]
Fogliano, V [1 ]
机构
[1] Univ Naples Federico II, Dipartimento Sci Alimenti, I-80055 Naples, Italy
关键词
D O I
10.1046/j.1365-2036.2003.01429.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Background: The consumption of unfiltered coffee, containing bioactive diterpenes, causes an increase in plasma homocysteine concentration. A slight increase in plasma homocysteine is also caused by large quantities of filtered coffee. Coffee terpenes also raise plasma glutathione in mice. Aim: To verify the effect of Italian-style coffee consumption on the plasma concentration of glutathione and homocysteine in healthy subjects. Methods: Twenty-two volunteers consumed five cups of coffee per day for 1 week and maintained their usual diet. Five subjects were enrolled as controls. The intervention trial was preceded and followed by seven coffee-free days. Results: Plasma glutathione increased by 16% (P < 0.05) on coffee consumption, and returned to the original concentration after the washout period. The increase in plasma homocysteine concentration (13% after 1 week of coffee intake) was not significant. No differences in glutathione or homocysteine concentration were observed in the control group. No variation of plasma hydroperoxide concentration was detectable. Conclusions: A coffee intake regimen, representing the average consumption of coffee drinkers in Italy, increased the plasma concentration of glutathione, but no significant increase in the plasma homocysteine concentration was detected.
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页码:595 / 601
页数:7
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