Mitochondria as central hub of the immune system

被引：209

作者：

de Souza Breda, Cristiane Naffah ^{[1
]}

Davanzo, Gustavo Gastao ^{[2
]}

Basso, Paulo Jose ^{[1
]}

Saraiva Camara, Niels Olsen ^{[1
]}

Mendes Moraes-Vieira, Pedro Manoel ^{[2
]}

机构：

[1] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Transplantat Immunobiol Lab, Ave Prof Lineu Prestes 1730,ICB 4,Sala 238, BR-05508000 Sao Paulo, Brazil

[2] Univ Estadual Campinas, Lab Immunometab, Dept Genet Evolut Microbiol & Immunol, Inst Biol, St Monteiro Lobato 255,Cidade Univ Zeferino Vaz, BR-13083970 Campinas, SP, Brazil

来源：

REDOX BIOLOGY | 2019年 / 26卷

基金：

巴西圣保罗研究基金会;

关键词：

Immunometabolism; Mitochondrial function; Cell fate; And immune cells; T-CELL-ACTIVATION; OXIDATIVE SIGNALING ORGANELLES; EXTRACELLULAR TRAP FORMATION; FATTY-ACID OXIDATION; NF-KAPPA-B; NADPH OXIDASE; SUCCINATE-DEHYDROGENASE; PHYSIOLOGICAL FUNCTIONS; METABOLIC REQUIREMENTS; SUPEROXIDE-PRODUCTION;

D O I：

10.1016/j.redox.2019.101255

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Nearly 130 years after the first insights into the existence of mitochondria, new rolesassociated with these organelles continue to emerge. As essential hubs that dictate cell fate, mitochondria integrate cell physiology, signaling pathways and metabolism. Thus, recent research has focused on understanding how these multifaceted functions can be used to improve inflammatory responses and prevent cellular dysfunction. Here, we describe the role of mitochondria on the development and function of immune cells, highlighting metabolic aspects and pointing out some metabolic- independent features of mitochondria that sustain cell function.

引用

页数：17

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