DNA repair defects in colon cancer

被引：65

作者：

Jiricny, J ^{[1
]}

Marra, G ^{[1
]}

机构：

[1] Univ Zurich, Inst Mol Canc Res, CH-8008 Zurich, Switzerland

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2003年 / 13卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(03)00004-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Defects in DNA-repair pathways lead to an accumulation of mutations in genomic DNA that result from non-repair or mis-repair of modifications introduced into the DNA by endogenous or exogenous agents or by the malfunction of DNA metabolic pathways. Until recently, only two repair pathways, postreplicative mismatch repair and nucleotide excision repair, have been linked to cancer in mammals, but these have been joined in recent months also by the damage-reversal and base-excision-repair processes, which have been shown to be inactivated, either through mutation or epigenetically, in human cancer.

引用

页码：61 / 69

页数：9

共 83 条

[51] MLH3:: a DNA mismatch repair gene associated with mammalian microsatellite instability [J].

Lipkin, SM ;

Wang, V ;

Jacoby, R ;

Banerjee-Basu, S ;

Baxevanis, AD ;

Lynch, HT ;

Elliott, RM ;

Collins, FS .

NATURE GENETICS, 2000, 24 (01) :27-35

[52] Somatic mutation of hPMS2 as a possible cause of sporadic human colon cancer with microsatellite instability [J].

Ma, AH ;

Xia, L ;

Littman, SJ ;

Swinler, S ;

Lader, G ;

Polinkovsky, A ;

Olechnowicz, J ;

Kasturi, L ;

Lutterbaugh, J ;

Modrich, P ;

Veigl, ML ;

Markowitz, SD ;

Sedwick, WD .

ONCOGENE, 2000, 19 (18) :2249-2256

[53] Enhanced CpG mutability and tumorigenesis in MBD4-deficient mice [J].

Millar, CB ;

Guy, J ;

Sansom, OJ ;

Selfridge, J ;

MacDougall, E ;

Hendrich, B ;

Keightley, PD ;

Bishop, SM ;

Clarke, AR ;

Bird, A .

SCIENCE, 2002, 297 (5580) :403-405

[54] Mmh/Ogg1 gene inactivation results in accumulation of 8-hydroxyguanine in mice [J].

Minowa, O ;

Arai, T ;

Hirano, M ;

Monden, Y ;

Nakai, S ;

Fukuda, M ;

Itoh, M ;

Takano, H ;

Hippou, Y ;

Aburatani, H ;

Masumura, K ;

Nohmi, T ;

Nishimura, S ;

Noda, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (08) :4156-4161

[55] MOLECULAR ANALYSIS OF O-6-SUBSTITUTED GUANINE-INDUCED MUTAGENESIS OF RAS ONCOGENES [J].

MITRA, G ;

PAULY, GT ;

KUMAR, R ;

PEI, GK ;

HUGHES, SH ;

MOSCHEL, RC ;

BARBACID, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :8650-8654

[56] Human DNA glycosylases of the bacterial Fpg/MutM superfamily:: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA [J].

Morland, I ;

Rolseth, V ;

Luna, L ;

Rognes, T ;

Bjorås, M ;

Seeberg, E .

NUCLEIC ACIDS RESEARCH, 2002, 30 (22) :4926-4936

[57] Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase [J].

Neddermann, P ;

Gallinari, P ;

Lettieri, T ;

Schmid, D ;

Truong, O ;

Hsuan, JJ ;

Wiebauer, K ;

Jiricny, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (22) :12767-12774

[58]

Nikitin AY, 2002, CANCER RES, V62, P5134

[59] Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase [J].

Nilsen, H ;

Haushalter, KA ;

Robins, P ;

Barnes, DE ;

Verdine, GL ;

Lindahl, T .

EMBO JOURNAL, 2001, 20 (15) :4278-4286

[60] DNA mismatch repair and cancer [J].

Peltomäki, P .

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 2001, 488 (01) :77-85

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