Searching genomes for ribozymes and riboswitches

被引：42

作者：

Hammann, Christian

Westhof, Eric

机构：

[1] Univ Strasbourg, Inst Biol Mol & Cellulaire, CNRS, Architecture & Reactivite ARN, F-67084 Strasbourg, France

[2] Univ Kassel, Dept Genet, Res Grp Mol Interact, D-34132 Kassel, Germany

来源：

GENOME BIOLOGY | 2007年 / 8卷 / 04期

关键词：

D O I：

10.1186/gb-2007-8-4-210

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New regulatory RNAs with complex structures have recently been discovered, among them the first catalytic riboswitch, a gene-regulatory RNA sequence with catalytic activity. Here we discuss some of the experimental approaches and theoretical difficulties attached to the identification of new ribozymes in genomes.

引用

页数：11

共 117 条

[91] In vitro evolution suggests multiple origins for the hammerhead ribozyme [J].

Salehi-Ashtiani, K ;

Szostak, JW .

NATURE, 2001, 414 (6859) :82-84

[92] A genomewide search for ribozymes reveals an HDV-like sequence in the human CPEB3 gene [J].

Salehi-Ashtiani, Kourosh ;

Luptak, Andrej ;

Litovchick, Alexander ;

Szostak, Jack W. .

SCIENCE, 2006, 313 (5794) :1788-1792

[93] A SITE-SPECIFIC SELF-CLEAVAGE REACTION PERFORMED BY A NOVEL RNA IN NEUROSPORA MITOCHONDRIA [J].

SAVILLE, BJ ;

COLLINS, RA .

CELL, 1990, 61 (04) :685-696

[94] One sequence, two ribozymes: Implications for the emergence of new ribozyme folds [J].

Schultes, EA ;

Bartel, DP .

SCIENCE, 2000, 289 (5478) :448-452

[95] FROM SEQUENCES TO SHAPES AND BACK - A CASE-STUDY IN RNA SECONDARY STRUCTURES [J].

SCHUSTER, P ;

FONTANA, W ;

STADLER, PF ;

HOFACKER, IL .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1994, 255 (1344) :279-284

[96] Parallel selections in vitro reveal a preference for 2′-5′ RNA ligation upon deoxyribozyme-mediated opening of a 2′,3′-cyclic phosphate [J].

Semlow, DR ;

Silverman, SK .

JOURNAL OF MOLECULAR EVOLUTION, 2005, 61 (02) :207-215

[97] Novel RNA catalysts for the Michael reaction [J].

Sengle, G ;

Eisenführ, A ;

Arora, PS ;

Nowick, JS ;

Famulok, M .

CHEMISTRY & BIOLOGY, 2001, 8 (05) :459-473

[98] Ribozyme cleavage of a 2′,5′-phosphodiester linkage:: Mechanism and a restricted divalent metal-ion requirement [J].

Shih, IH ;

Been, MD .

RNA, 1999, 5 (09) :1140-1148

[99] An mRNA structure in bacteria that controls gene expression by binding lysine [J].

Sudarsan, N ;

Wickiser, JK ;

Nakamura, S ;

Ebert, MS ;

Breaker, RR .

GENES & DEVELOPMENT, 2003, 17 (21) :2688-2697

[100] Viroids: petite RNA pathogens with distinguished talents [J].

Tabler, M ;

Tsagris, M .

TRENDS IN PLANT SCIENCE, 2004, 9 (07) :339-348

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