Preparation and in vivo investigation of artificial cornea made of nano-hydroxyapatite/poly (vinyl alcohol) hydrogel composite

被引：35

作者：

Xu Fenglan

Li Yubao ^{[1
]}

Yao Xiaoming

Liao Hongbing

Zhang Li

机构：

[1] Sichuan Univ, Analyt & Testing Ctr, Res Ctr Nanobiomat, Chengdu 610064, Peoples R China

[2] Shenzhen Eye Ophthalm Hosp, Shenzhen 518001, Peoples R China

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2007年 / 18卷 / 04期

关键词：

D O I：

10.1007/s10856-007-2313-5

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

An artificial cornea consisted of a porous nano-hydroxyapatite/poly (vinyl alcohol) hydrogel (n-HA/PVAH) skirt and a transparent center poly (vinyl alcohol) hydrogel (PVA-H) were prepared. The n-HA/PVA-H skirt was homogeneously porous and these pores were interconnected. Inter-penetrating network was observed along the interface between the core and the skirt. Artificial corneas were implanted in eyes of rabbit. The corneal tissues were evaluated histological. The results displayed that a good biocompatibility and interlocking had happened between artificial cornea and host tissues. This novel cornea prepared here is potential to be used clinically.

引用

页码：635 / 640

页数：6

共 23 条

[1] An overview of the development of artificial corneas with porous skirts and the use of PHEMA for such an application [J].