Common variants in FOXP1 are associated with generalized vitiligo

被引：75

作者：

Jin, Ying ^{[1
,2
]}

Birlea, Stanca A. ^{[1
,3
]}

Fain, Pamela R. ^{[1
,2
,4
]}

Mailloux, Christina M. ^{[1
]}

Riccardi, Sheri L. ^{[1
]}

Gowan, Katherine ^{[1
]}

Holland, Paulene J. ^{[1
]}

Bennett, Dorothy C. ^{[5
]}

Wallace, Margaret R. ^{[6
]}

McCormack, Wayne T. ^{[7
]}

Kemp, E. Helen ^{[8
]}

Gawkrodger, David J. ^{[9
]}

Weetman, Anthony P. ^{[8
]}

Picardo, Mauro ^{[10
]}

Leone, Giovanni ^{[10
]}

Taieb, Alain ^{[11
]}

Jouary, Thomas ^{[11
]}

Ezzedine, Khaled ^{[11
]}

van Geel, Nanny ^{[12
]}

Lambert, Jo ^{[12
]}

Overbeck, Andreas ^{[13
]}

Spritz, Richard A. ^{[1
,2
]}

机构：

[1] Univ Colorado, Sch Med, Human Med Genet Program, Aurora, CO USA

[2] Univ Colorado, Sch Med, Dept Pediat, Aurora, CO USA

[3] Univ Colorado, Sch Med, Dept Dermatol, Aurora, CO USA

[4] Univ Colorado, Sch Med, Barbara Davis Ctr Childhood Diabet, Aurora, CO USA

[5] Univ London, Div Basic Med Sci, London, England

[6] Univ Florida, Coll Med, Dept Mol Genet & Microbiol, Gainesville, FL USA

[7] Univ Florida, Coll Med, Dept Pathol Immunol & Lab Med, Gainesville, FL USA

[8] Univ Sheffield, Sch Med, Dept Human Metab, Sheffield, S Yorkshire, England

[9] Royal Hallamshire Hosp, Dept Dermatol, Sheffield S10 2JF, S Yorkshire, England

[10] Ist Dermatol S Maria & S Gallicano, Lab Fisiopatol Cutanea, Rome, Italy

[11] Hop St Andre, Dept Dermatol, Ctr Reference Malad Rares Peau, Bordeaux, France

[12] Ghent Univ Hosp, Dept Dermatol, B-9000 Ghent, Belgium

[13] Lumiderm, Madrid, Spain

来源：

NATURE GENETICS | 2010年 / 42卷 / 07期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; ESSENTIAL TRANSCRIPTIONAL REGULATOR; T-CELLS; SUSCEPTIBILITY LOCI; AUTOIMMUNITY; GENETICS; DISEASES; IDDM8;

D O I：

10.1038/ng.602

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

In a recent genome-wide association study of generalized vitiligo, we identified ten confirmed susceptibility loci. By testing additional loci that showed suggestive association in the genome-wide study, using two replication cohorts of European descent, we observed replicated association of generalized vitiligo with variants at 3p13 encompassing FOXP1 (rs17008723, combined P = 1.04 x 10(-8)) and with variants at 6q27 encompassing CCR6 (rs6902119, combined P = 3.94 x 10(-7)).

引用

页码：576 / 578

页数：3

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