The glycosyltransferase gene encoding the enzyme catalyzing the first step of mycothiol biosynthesis (mshA)

被引：70

作者：

Newton, GL

Koledin, T

Gorovitz, B

Rawat, M

Fahey, RC ^{[1
]}

Av-Gay, Y

机构：

[1] Univ Calif San Diego, Dept Chem & Biochem, La Jolla, CA 92093 USA

[2] Univ British Columbia, Dept Med, Div Infect Dis, Vancouver, BC V5Z 3J5, Canada

来源：

JOURNAL OF BACTERIOLOGY | 2003年 / 185卷 / 11期

关键词：

D O I：

10.1128/JB.185.11.3476-3479.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Mycothiol is the major thiol present in most actinomycetes and is produced from the pseudodisaccharide 1D-myo-inosityl 2-acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins). A transposon mutant of Mycobacterium smegmatis shown to be GlcNAc-Ins and mycothiol deficient was sequenced to identify a putative glycosyltransferase gene designated mshA. The ortholog in Mycobacterium tuberculosis, Rv0486, was used to complement the mutant phenotype.

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页码：3476 / 3479

页数：4

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