Function and regulation of Aurora/Ipl1p kinase family in cell division

被引：62

作者：

Ke, YW

Dou, Z

Zhang, J

Yao, XB ^{[1
]}

机构：

[1] Univ Sci & Technol China, Lab Cell Dynam, Sch Life Sci, Hefei 230027, Peoples R China

[2] Univ Calif Berkeley, Dept Mol & Cell Biol, Berkeley, CA 94720 USA

来源：

CELL RESEARCH | 2003年 / 13卷 / 02期

关键词：

Aurora (Ipl1p); mitosis and cancer;

D O I：

10.1038/sj.cr.7290152

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

During mitosis, the parent cell distributes its genetic materials equally into two daughter cells through chromosome segregation, a complex movements orchestrated by mitotic kinases and its effector proteins. Faithful chromosome segregation and cytokinesis ensure that each daughter cell receives a full copy of genetic materials of parent cell. Defects in these processes can lead to aneuploidy or polyploidy. Aurora/Ipl1p family, a class of conserved serine/threonine kinases, plays key roles in chromosome segregation and cytokinesis. This article highlights the function and regulation of Aurora/Ipl1p family in mitosis and provides potential links between aberrant regulation of Aurora/Ipl1p kinases and pathogenesis, of human cancer.

引用

收藏

页码：69 / 81

页数：13

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