Inhibition of aldose reductase by maesanin and related p-benzoquinone derivatives and effects on other enzymes

被引：14

作者：

Haraguchi, H

Ohmi, I

Kubo, I

机构：

[1] FUKUYAMA UNIV, FAC ENGN, FUKUYAMA, HIROSHIMA 72902, JAPAN

[2] UNIV CALIF BERKELEY, DEPT ENVIRONM SCI POLICY & MANAGEMENT, BERKELEY, CA 94720 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 1996年 / 4卷 / 01期

关键词：

D O I：

10.1016/0968-0896(95)00162-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A naturally occurring p-benzoquinone derivative, maesanin, inhibited porcine lens aldose reductase. Systematic investigation of related p-benzoquinone derivatives revealed that 2,5-dihydroxy-p-benzoquinone was a potent inhibitor of aldose reductase and aldehyde reductase but had no effect on NADH oxidase. Kinetic analysis showed this p-benzoquinone exhibited uncompetitive inhibition against DL-glyceraldehyde and noncompetitive inhibition against NADPH.

引用

页码：49 / 53

页数：5

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