Mice fed lipid-encapsulated Mycobacterium bovis BCG are protected against aerosol challenge with Mycobacterium tuberculosis

被引：26

作者：

Aldwell, FE

Brandt, L

Fitzpatrick, C

Orme, IM

机构：

[1] Univ Otago, Dept Microbiol & Immunol, Dunedin, New Zealand

[2] Colorado State Univ, Dept Microbiol Immunol & Pathol, Ft Collins, CO USA

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 03期

关键词：

D O I：

10.1128/IAI.73.3.1903-1905.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mice that consumed a single dose of 107 lipid-encapsulated Mycobacterium bovis BCG bacilli showed significant pulmonary and systemic protection against aerosol challenge with M. tuberculosis H37Rv. As an extension of previous challenge studies with virulent strains of M. bovis, this report describes a reduction in M. tuberculosis infection in mice vaccinated orally with lipid-encapculated BCG comparable to that observed in mice vaccinated subcutaneously with BCG. These results are consistent with the induction of tuberculin-specific cell-mediated immune responses.

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页码：1903 / 1905

页数：3

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