Stroma in breast development and disease

被引：92

作者：

Arendt, Lisa M. ^{[1
,2
]}

Rudnick, Jenny A. ^{[1
,2
]}

Keller, Patricia J. ^{[1
,2
]}

Kuperwasser, Charlotte ^{[1
,2
]}

机构：

[1] Tufts Univ, Sch Med, Dept Anat & Cellular Biol, Sackler Sch, Boston, MA 02111 USA

[2] Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2010年 / 21卷 / 01期

关键词：

Mammary development; Breast cancer; Tumorigenesis; Stroma; Cancer-associated fibroblasts; MAMMARY-GLAND DEVELOPMENT; GROWTH-FACTOR-BETA; ESTROGEN-RECEPTOR-ALPHA; CARCINOMA-ASSOCIATED FIBROBLASTS; HORMONE REPLACEMENT THERAPY; MAMMOGRAPHIC DENSITY; TUMOR STROMA; GENE-EXPRESSION; MESENCHYMAL TRANSITION; EPITHELIAL-CELLS;

D O I：

10.1016/j.semcdb.2009.10.003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It is increasingly apparent that normal and malignant breast tissues require complex local and systemic stromal interactions for development and progression. During development, mammary cell fate specification and differentiation require highly regulated contextual signals derived from the stroma. Likewise, during breast carcinoma development, the tissue stroma can provide tumor suppressing and tumor-promoting environments that serve to regulate neoplastic growth of the epithelium. This review focuses on the role of the stroma as a mediator of normal mammary development, as well as a critical regulator of malignant conversion and progression in breast cancer. Recognition of the important role of the stroma during the progression of breast cancers leads to the possibility of new targets for treatment of the initial breast cancer lesion as well as prevention of recurrence. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：11 / 18

页数：8

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