Green coffee extract enhances oxidative stress resistance and delays aging in Caenorhabditis elegans

被引：43

作者：

Amigoni, Loredana ^{[1
]}

Stuknyte, Milda ^{[2
]}

Ciaramelli, Carlotta ^{[1
]}

Magoni, Chiara ^{[1
]}

Bruni, Ilaria ^{[1
]}

De Noni, Ivano ^{[2
]}

Airoldi, Cristina ^{[1
,3
]}

Regonesi, Maria Elena ^{[1
,3
]}

Palmioli, Alessandro ^{[1
]}

机构：

[1] Univ Milano Bicocca, Dipartimento Biotecnol & Biosci, Piazza Sci 2, I-20126 Milan, Italy

[2] Univ Milan, Dipartimento Sci Alimenti Nutr & Ambiente, Via Celoria 2, I-20133 Milan, Italy

[3] Milan Ctr Neurosci NeuroMI, Via Pergolesi 33,20052, I-20126 Monza, Italy

来源：

JOURNAL OF FUNCTIONAL FOODS | 2017年 / 33卷

关键词：

Green coffee extract; Chlorogenic acids; Antioxidant activity; High resolution mass spectrometry; NMR spectroscopy; Caenorhabditis elegans; NMR-BASED METABOLOMICS; LIFE-SPAN; ANTIOXIDANT ACTIVITY; CHLOROGENIC ACID; PHENOLIC-COMPOUNDS; REPRODUCTION; RESVERATROL; POLYPHENOLS; LONGEVITY; CAPACITY;

D O I：

10.1016/j.jff.2017.03.056

中图分类号：

TS2 [食品工业];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Nutritional factors play a pivotal role for healthy aging and longevity. This is related to the antioxidant properties of the molecules present in some foods. Due to the high content of polyphenols, Green Coffee Extract (GCE) is a powerful antioxidant. Nevertheless, little is known about its effect on aging. We demonstrated the benefit effects of GCE on stress resistance, fertility and adult mean lifespan using Caenorhabditis elegans as a model. The mean and maximum lifespan of worms treated with GCE increased significantly in a dose-dependent manner, and animals pre-treated were more resistant to oxidative stress. NMR and UPLC/ESI-HRMS analyses of GCE confirmed a significant content of chlorogenic acids, being 5-O-caffeoylquinic acid (5-CQA) the most abundant isomer. The major activity demonstrated by GCE in comparison to the pure 5-CQA on C. elegans phenotypes clearly demonstrated the importance of the employment of a natural extract to develop functional foods and supplements. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：297 / 306

页数：10

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