Cloning and localization of C2orf2ropp120, a previously unknown WD repeat protein

被引：12

作者：

Heidebrecht, HJ

Buck, F

Pollmann, M

Siebert, R

Parwaresch, R

机构：

[1] Univ Kiel, Dept Hematopathol, D-24105 Kiel, Germany

[2] Univ Kiel, German Assoc Pathologists, Lymph Node Registry, D-24105 Kiel, Germany

[3] Univ Hamburg, Inst Cell Biochem & Clin Neurobiol, Hamburg, Germany

[4] Univ Kiel, Dept Human Genet, Kiel, Germany

来源：

GENOMICS | 2000年 / 68卷 / 03期

关键词：

D O I：

10.1006/geno.2000.6301

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Ropp 120 (restrictedly overexpressed proliferation-associated protein) is a cytoplasmic protein of 120 kDa that is significantly overexpressed in mitotic cells. Protein sequencing of the immunoaffinity purified 120-kDa protein showed it to be an as yet unknown protein. DNA sequencing revealed a cDNA sequence of 3419 bases, which includes the complete coding region of ropp120 of 2943 bases (981 amino acids). Analysis of the deduced amino acid sequence showed that ropp 120 contains four WD repeats and a well-conserved consensus sequence of serine proteases. The gene encoding ropp120 (HGMW-approved gene symbol C2orf2) was assigned to chromosome 2p21-p22 by means of radiation hybrid and fluorescence in situ hybridization mapping. (C) 2000 Academic Press.

引用

页码：348 / 350

页数：3

共 9 条

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