Prenylflavonoids and prenyl/alkyl-phloroacetophenones: Synthesis and antitumour biological evaluation

被引：50

作者：

Basabe, P. ^{[1
]}

de Roman, M. ^{[1
]}

Marcos, I. S. ^{[1
]}

Diez, D. ^{[1
]}

Blanco, A. ^{[1
]}

Bodero, O. ^{[1
]}

Mollinedo, F. ^{[2
]}

Sierra, B. G. ^{[2
,3
]}

Urones, J. G. ^{[1
]}

机构：

[1] Univ Salamanca, Dept Quim Organ, Fac Ciencias Quim, E-37008 Salamanca, Spain

[2] Univ Salamanca, CSIC, Ctr Invest Canc, Salamanca 37007, Spain

[3] Univ Salamanca, APOINTECH, Salamanca 37007, Spain

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2010年 / 45卷 / 09期

关键词：

Prenylflavonoids; Prenyl-phloroacetophenones; Antitumourals; C-Alkylation; Flavonoids; NATURAL-PRODUCT HYBRIDS; ENT-HALIMIC ACID; PRENYLATED FLAVONOIDS; DRUG DISCOVERY; SESTERTERPENOLIDES; PHLOROGLUCINOL; DERIVATIVES; LUFFOLIDE;

D O I：

10.1016/j.ejmech.2010.06.025

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Several prenylflavonoids have been synthesised and tested against human tumour cell lines. The prenyl unit has been geranyl or a labdane diterpene. These labdane-flavonoids have been synthesised for the first time. The antitumour activity increase with the prenylation at C-8 position. Twenty-three C and O-prenylated acylphloroglucinols have been synthesised as well. In this case the C-alkylation products have resulted, in general, more active. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：4258 / 4269

页数：12

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