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Sphincter incontinence: Is regenerative medicine the best alternative to restore urinary or anal sphincter function?

被引：28
作者：
Feki, A.
Faltin, D. L.
Lei, T.
Dubuisson, J. -B.
Jacob, S.
Irion, O.
机构：
[1] Univ Hosp Geneva, Dept Obstet & Gynecol, Geneva, Switzerland
[2] Ctr Perineol Dianuro, Geneva, Switzerland
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2007年 / 39卷 / 04期
关键词：
sphincter; incontinence; cell therapy; stem cell; aging;
D O I：
10.1016/j.biocel.2006.11.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Incontinence is a major public health concern in aging societies. It is caused by age-dependent spontaneous apoptosis of muscle cells in the urinary and fecal sphincters, and is aggravated in women due to birth trauma. Compared to other currently employed invasive surgical management techniques associated with morbidity and recurrence, replacement or regeneration of dysfunctional sphincter through stem cell therapy and tissue engineering techniques hold great promise. This review focuses on the pathophysiological analysis of urinary incontinence and the possible application of muscle-derived-stem cells, satellite cells, chondrocytes and adipose-derived-stem cells in restoring sphincter functions. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：678 / 684
页数：7
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