A new mutation Rim3 resembling Reden is mapped close to retinoic acid receptor alpha (Rara) gene on mouse Chromosome 11

被引：60

作者：

Sato, H

Koide, T

Masuya, H

Wakana, S

Sagai, T

Umezawa, A

Ishiguro, S

Tama, M

Shiroishi, T

机构：

[1] Natl Inst Genet, Mammalian Genet Lab, Shizuoka 411, Japan

[2] Tohoku Univ, Sch Med, Dept Ophthalmol, Sendai, Miyagi 980, Japan

[3] Cent Inst Expt Anim, Kawasaki, Kanagawa 216, Japan

[4] Keio Univ, Sch Med, Dept Pathol, Shinjuku Ku, Tokyo 160, Japan

来源：

MAMMALIAN GENOME | 1998年 / 9卷 / 01期

关键词：

D O I：

10.1007/s003359900673

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A new mouse mutation, recombination-induced mutation 3 (Rim3), arose spontaneously in our mouse facility. This mutation exhibits corneal opacity as well as abnormal skin and hair development resembling rex denuded (Re-den) and bareskin (Bsk). Large-scale linkage analysis with two kinds of intersubspecific backcrosses revealed that Rim3 is mapped to the distal portion of Chromosome (Chr) II, in which Re-den and Bsk have been located, and is very close to the retinoic acid receptor, alpha (Rara). The genes, keratin gene complex-1, acidic, gene 10, 12 (Krt1-10, 12), granulin (Grn), junctional plakoglobin (Jup) and Rara, all of which regulate growth and differentiation of epithelial cells, are genetically excluded as candidate genes for Rim3, but are clustered in the shea segment on mouse Chr 11.

引用

页码：20 / 25

页数：6

共 37 条

[1] Mice expressing a mutant desmosomal cadherin exhibit abnormalities in desmosomes, proliferation, and epidermal differentiation [J].