Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene

被引：105

作者：

Weng, Yufang ^{[1
]}

Xiang, Lan ^{[2
]}

Matsuura, Akira ^{[3
]}

Zhang, Yang ^{[4
]}

Huang, Qianming ^{[4
]}

Qi, Jianhua ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

[2] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Hangzhou 310029, Zhejiang, Peoples R China

[3] Chiba Univ, Fac Sci, Dept Biol, Inage Ku, Chiba 2638522, Japan

[4] Sichuan Agr Univ, Coll Biol & Sci, Yaan 625014, Sichuan Prov, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2010年 / 18卷 / 03期

关键词：

Anti-aging ergosterol; Spores of Ganoderma lucidum; Yeast K6001 strain; UTH1; gene; NEURITOGENIC STEROID GLYCOSIDES; STARFISH LINCKIA-LAEVIGATA; SACCHAROMYCES-CEREVISIAE; ALZHEIMERS-DISEASE; LIFE-SPAN; RESVERATROL; ACTIVATORS; PROTEIN; STRESS;

D O I：

10.1016/j.bmc.2009.12.070

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Two novel ergosterol derivatives, ganodermasides A and B, hydroxylated at C-15 were isolated from the methanol extract of spores of a medicinal mushroom, Ganoderma lucidum, showed to extend the replicative life span of Saccharomyces cerevisiae, a yeast of K6001 strain. The stereostructures of ganodermasides A and B were determined based on the spectroscopic analysis and comparison of spectroscopic data. These new sterols have a 4, 6, 8(14), 22-tetraene-3-one unit with a unique hydroxylation at C-15. The anti-aging activity of these compounds on yeast is comparable to a well-known substance, resveratrol. Based on results of the investigation of the mechanism of biological activity, ganodermasides A and B regulated UTH1 expression in order to extend the replicative life span of yeast. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：999 / 1002

页数：4

共 18 条

[1]

Variation in cytostatic constituents of a sponge-derived Gymnascella dankaliensis by manipulating the carbon source [J].

Amagata, Taro ;

Tanaka, Makoto ;

Yamada, Takeshi ;

Doi, Mitsunobu ;

Minoura, Katsuhiko ;

Ohishi, Hirofumi ;

Yamori, Takao ;

Numata, Atsushi .

JOURNAL OF NATURAL PRODUCTS, 2007, 70 (11) :1731-1740

[2]

Resveratrol - A boon for treating Alzheimer's disease? [J].

Anekonda, Thimmappa S. .

BRAIN RESEARCH REVIEWS, 2006, 52 (02) :316-326

[3]

Resveratrol improves health and survival of mice on a high-calorie diet [J].

Baur, Joseph A. ;

Pearson, Kevin J. ;

Price, Nathan L. ;

Jamieson, Hamish A. ;

Lerin, Carles ;

Kalra, Avash ;

Prabhu, Vinayakumar V. ;

Allard, Joanne S. ;

Lopez-Lluch, Guillermo ;

Lewis, Kaitlyn ;

Pistell, Paul J. ;

Poosala, Suresh ;

Becker, Kevin G. ;

Boss, Olivier ;

Gwinn, Dana ;

Wang, Mingyi ;

Ramaswamy, Sharan ;

Fishbein, Kenneth W. ;

Spencer, Richard G. ;

Lakatta, Edward G. ;

Le Couteur, David ;

Shaw, Reuben J. ;

Navas, Placido ;

Puigserver, Pere ;

Ingram, Donald K. ;

de Cabo, Rafael ;

Sinclair, David A. .

NATURE, 2006, 444 (7117) :337-342

[4]

Uth1p:: a yeast mitochondrial protein at the crossroads of stress, degradation and cell death [J].

Camougrand, N ;

Kissová, I ;

Velours, G ;

Manon, S .

FEMS YEAST RESEARCH, 2004, 5 (02) :133-140

[5]

Aging: An important factor for the pathogenesis of neurodegenerative diseases [J].

Farooqui, Tahira ;

Farooqui, Akhlaq A. .

MECHANISMS OF AGEING AND DEVELOPMENT, 2009, 130 (04) :203-215

[6]

Structure-activity relationships of novel neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata [J].

Han, Chunguang ;

Qi, Jianhua ;

Ojika, Makoto .

BIOORGANIC & MEDICINAL CHEMISTRY, 2006, 14 (13) :4458-4465

[7]

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan [J].

Howitz, KT ;

Bitterman, KJ ;

Cohen, HY ;

Lamming, DW ;

Lavu, S ;

Wood, JG ;

Zipkin, RE ;

Chung, P ;

Kisielewski, A ;

Zhang, LL ;

Scherer, B ;

Sinclair, DA .

NATURE, 2003, 425 (6954) :191-196

[8]

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase [J].

Imai, S ;

Armstrong, CM ;

Kaeberlein, M ;

Guarente, L .

NATURE, 2000, 403 (6771) :795-800

[9]

A novel assay for replicative lifespan in Saccharomyces cerevisiae [J].

Jarolim, S ;

Millen, J ;

Heeren, G ;

Laun, P ;

Goldfarb, DS ;

Breitenbach, M .

FEMS YEAST RESEARCH, 2004, 5 (02) :169-177

[10]

Metabolic-state-dependent remodeling of the transcriptome in response to anoxia and subsequent reoxygenation in Saccharomyces cerevisiae [J].

Lai, Liang-Chuan ;

Kosorukoff, Alexander L. ;

Burke, Patricia V. ;

Kwast, Kurt E. .

EUKARYOTIC CELL, 2006, 5 (09) :1468-1489

← 1 2 →