Clinical and laboratory characteristics of patients with atherothrombotic risk factors presenting with low concentrations of highly sensitive C-reactive protein

被引：18

作者：

Zeltser, D ^{[1
]}

Rogowski, O ^{[1
]}

Mardi, T ^{[1
]}

Justo, D ^{[1
]}

Tolshinsky, T ^{[1
]}

Goldin, Y ^{[1
]}

Burke, M ^{[1
]}

Deutsch, V ^{[1
]}

Berliner, S ^{[1
]}

Shapira, I ^{[1
]}

机构：

[1] Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Dept Internal Med D, IL-69978 Tel Aviv, Israel

来源：

ATHEROSCLEROSIS | 2004年 / 176卷 / 02期

关键词：

C-reactive protein; atherothrombosis; low-grade inflammation;

D O I：

10.1016/j.atherosclerosis.2004.04.015

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims: To clarify whether individuals with low concentrations of highly sensitive C-reactive protein (hs-CRP) are free of atherothrombotic risk factors or low-grade inflammation. Methods and results: This cross-sectional study included 1266 individuals with risk factors (diabetes, hypertension, hyperlipidemia, smoking, obesity). Eighty percent of women and the same percentage of men with a low concentration (0.8 +/- 0.4 mg/l) of hs-CRP had at least one atherothrombotic risk factor. About one-fourth of the females and a one-third of the males with a low concentration of hs-CRP had at least one laboratory marker of chronic inflammation (erythrocyte sedimentation rate (ESR), white blood cell count (WBCC) or fibrinogen concentration) in the upper 75th percentile. Conclusion: Individuals presenting with low concentrations of hs-CRP are not necessarily free of atherothrombotic risk factors. One-fourth of the females and a third of the males in this group presented laboratory evidence of a low-grade inflammation as detected by increased erythrocyte sedimentation rate, white blood cell count or fibrinogen concentration. (C) 2004 Elsevier Ireland Ltd. All rights reserved.

引用

页码：297 / 301

页数：5

共 14 条

[1] Concentration in plasma of macrophage inhibitory cytokine-1 and risk of cardiovascular events in women: a nested case-control study [J].