5-HT2A receptor stimulation by DOI, a 5-HT2A/2C receptor agonist, potentiates amphetamine-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens

被引：46

作者：

Kuroki, T

Meltzer, HY

Ichikawa, J

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Neuropsychiat, Fukuoka 8128582, Japan

[2] Vanderbilt Univ, Sch Med, Psychopharmacol Div, Dept Psychiat, Nashville, TN 37212 USA

[3] Vanderbilt Univ, Sch Med, Psychopharmacol Div, Dept Pharmacol, Nashville, TN 37212 USA

来源：

BRAIN RESEARCH | 2003年 / 972卷 / 1-2期

关键词：

1-(2,5-dimethoxy-4-iodophenyl)-aminopropane]-hydrochloride; M100907; 5-HT2A receptor; amphetamine; dopa-mine; microdialysis; rat;

D O I：

10.1016/S0006-8993(03)02516-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

(+/-)-([1-(2,5-Dimethoxy-4-iodophenyl)-aminopropane]-hydrochloride) (DOI) (2.5 mg/kg), a 5-HT2A/2C agonist, significantly potentiated D-amphetamine (AMPH) (1 mg/kg)-induced dopamine (DA) release in rat medial prefrontal cortex (mPFC) and nucleus accumbens (NAC). This effect of DOI was completely prevented by M100907 (1 mg/kg), a selective 5-HT2A antagonist, which by itself had no effect on basal and AMPH-induced DA release in either region. Thus, 5-HT2A receptor agonism potentiates AMPH-induced DA release in the mPFC and NAC. (C) 2003 Elsevier Science B,V. All rights reserved.

引用

收藏

页码：216 / 221

页数：6

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