Outside looking in: the inner workings of the crosspresentation pathway within dendritic cells

被引：33

作者：

Villadangos, Jose A.

Heath, William R.

Carbone, Francis R. ^{[1
]}

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

[2] Walter & Eliza Hall Inst Med Res, Div Immunol, Parkville, Vic 3050, Australia

来源：

TRENDS IN IMMUNOLOGY | 2007年 / 28卷 / 02期

关键词：

D O I：

10.1016/j.it.2006.12.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The entry of exogenous antigen into the MHC class I-restricted crosspresentation pathway can contribute to CD8+ T cell tolerance and immunity, in particular to peripheral self-antigens or selected viruses and bacteria showing restricted tissue tropism. Dendritic cells are the key crosspresenting cells and, as such, they are thought to carry specialized machinery dedicated to this purpose. Two recent papers describe intracellular components tailored to the dendritic cell crosspresentation pathway.

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收藏

页码：45 / 47

页数：3

相关论文

共 19 条

[1] Access of soluble antigens to the endoplasmic reticulum can explain cross-presentation by dendritic cells [J].

Ackerman, AL ;

Kyritsis, C ;

Tampé, R ;

Cresswell, P .

NATURE IMMUNOLOGY, 2005, 6 (01) :107-113

[2] Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens [J].

Ackerman, AL ;

Kyritsis, C ;

Tampé, R ;

Cresswell, P .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (22) :12889-12894

[3] A role for the endoplasmic reticulum protein retrotranslocation machinery during crosspresentation by dendritic cells [J].

Ackerman, Anne L. ;

Giodini, Alessandra ;

Cresswell, Peter .

IMMUNITY, 2006, 25 (04) :607-617

[4]

BEVAN MJ, 1976, J IMMUNOL, V117, P2233

[5] Cross-presentation: A general mechanism for CTL immunity and tolerance [J].

Carbone, FR ;

Kurts, C ;

Bennett, SRM ;

Miller, JFAP ;

Heath, WR .

IMMUNOLOGY TODAY, 1998, 19 (08) :368-373

[6] CLASS-I-RESTRICTED PROCESSING AND PRESENTATION OF EXOGENOUS CELL-ASSOCIATED ANTIGEN INVIVO [J].

CARBONE, FR ;

BEVAN, MJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (02) :377-387

[7] Differential lysosomal proteolysis in antigen-presenting CeRs determines antigen fate [J].

Delamarre, L ;

Pack, M ;

Chang, H ;

Mellman, I ;

Trombetta, ES .

SCIENCE, 2005, 307 (5715) :1630-1634

[8] Cryptic O2--generating NADPH oxidase in dendritic cells [J].

Elsen, S ;

Doussière, J ;

Villiers, CL ;

Faure, M ;

Berthier, R ;

Papaioannou, A ;

Grandvaux, N ;

Marche, PN ;

Vignais, PV .

JOURNAL OF CELL SCIENCE, 2004, 117 (11) :2215-2226

[9] Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages [J].

Gagnon, E ;

Duclos, S ;

Rondeau, C ;

Chevet, E ;

Cameron, PH ;

Steele-Mortimer, O ;

Paiement, J ;

Bergeron, JJM ;

Desjardins, M .

CELL, 2002, 110 (01) :119-131

[10] ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells [J].

Guermonprez, P ;

Saveanu, L ;

Kleijmeer, M ;

Davoust, J ;

van Endert, P ;

Amigorena, S .

NATURE, 2003, 425 (6956) :397-402