Ugi reaction for the synthesis of 4-aminopiperidine-4-carboxylic acid derivatives. Application to the synthesis of carfentanil and remifentanil

被引：38

作者：

Malaquin, Sandra

Jida, Mouhamad

Gesquiere, Jean-Claude

Deprez-Poulain, Rebecca

Deprez, Benoit ^{[1
]}

Laconde, Guillaume

机构：

[1] Univ Lille Nord France, Fac Pharm, INSERM, U761, F-59006 Lille, France

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 22期

关键词：

Ugi reaction; Remifentanil; Carfentanil; Mumm rearrangement; 4-COMPONENT CONDENSATION; AMINO-ACIDS; ISOCYANIDE;

D O I：

10.1016/j.tetlet.2010.03.120

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A two-step sequence involving an Ugi four-component reaction was developed for the preparation of 4-acid derivatives. This strategy has led to the successful preparation of two carfentanil and remifentanil in shorter times and better yields than previously described methods. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2983 / 2985

页数：3

共 18 条

[11] Rapid synthesis of diketopiperazine macroarrays via Ugi four-component reactions on planar solid supports [J].