Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes

被引：42

作者：

Beamer, Wesley G. ^{[1
]}

Shultz, Kathryn L. ^{[1
]}

Ackert-Bicknell, Cheryl L. ^{[1
]}

Horton, Lindsay G. ^{[1
]}

Delahunty, Krista M. ^{[1
]}

Coombs, Harold F., III ^{[1
]}

Donahue, Leah R. ^{[1
]}

Canalis, Ernesto ^{[1
]}

Rosen, Clifford J. ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 08期

关键词：

mouse congenic strains; quantitative trait loci; BMD; distal chromosome 1; sex;

D O I：

10.1359/JBMR.070419

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genetic analyses with mouse congenic strains for distal Chr1 have identified three closely linked QTLs regulating femoral vBMD, mid-diaphyseal cortical thickness, and trabecular microstructure in a sex-dependent fashion. The homologous relationship between distal mouse Chr 1 and human 1q21-24 offers the possibility of finding common regulatory genes for cortical and trabecular bone.

引用

收藏

页码：1187 / 1196

页数：10

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