Genetic dissection of mouse distal chromosome 1 reveals three linked BMD QTLs with sex-dependent regulation of bone phenotypes

被引：42

作者：

Beamer, Wesley G. ^{[1
]}

Shultz, Kathryn L. ^{[1
]}

Ackert-Bicknell, Cheryl L. ^{[1
]}

Horton, Lindsay G. ^{[1
]}

Delahunty, Krista M. ^{[1
]}

Coombs, Harold F., III ^{[1
]}

Donahue, Leah R. ^{[1
]}

Canalis, Ernesto ^{[1
]}

Rosen, Clifford J. ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 08期

关键词：

mouse congenic strains; quantitative trait loci; BMD; distal chromosome 1; sex;

D O I：

10.1359/JBMR.070419

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genetic analyses with mouse congenic strains for distal Chr1 have identified three closely linked QTLs regulating femoral vBMD, mid-diaphyseal cortical thickness, and trabecular microstructure in a sex-dependent fashion. The homologous relationship between distal mouse Chr 1 and human 1q21-24 offers the possibility of finding common regulatory genes for cortical and trabecular bone.

引用

收藏

页码：1187 / 1196

页数：10

相关论文

共 49 条

[11] Skeletal overexpression of gremlin impairs bone formation and causes osteopenia [J].

Gazzerro, E ;

Pereira, RC ;

Jorgetti, V ;

Olson, S ;

Economides, AN ;

Canalis, E .

ENDOCRINOLOGY, 2005, 146 (02) :655-665

[12] Genetic and environmental correlations between bone formation and bone mineral density: A twin study [J].

Harris, M ;

Nguyen, TV ;

Howard, GM ;

Kelly, PJ ;

Eisman, JA .

BONE, 1998, 22 (02) :141-145

[13] Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass [J].

Ioannidis, John P. A. ;

Ng, Mandy Y. ;

Sham, Pak C. ;

Zintzaras, Elias ;

Lewis, Cathryn M. ;

Deng, Hong-Wen ;

Econs, Michael J. ;

Karasik, David ;

Devoto, Marcella ;

Kammerer, Candace M. ;

Spector, Tim ;

Andrew, Toby ;

Cupples, L. Adrienne ;

Duncan, Emma L. ;

Foroud, Tatiana ;

Kiel, Douglas P. ;

Koller, Daniel ;

Langdahl, Bente ;

Mitchell, Braxton D. ;

Peacock, Munro ;

Recker, Robert ;

Shen, Hui ;

Sol-Church, Katia ;

Spotila, Loretta D. ;

Uitterlinden, Andre G. ;

Wilson, Scott G. ;

Kung, Annie W. C. ;

Ralston, Stuart H. .

JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 (02) :173-183

[14] Quantitative trait loci that determine BMD in C57BL/6J and 129S1/SvlmJ inbred mice [J].

Ishimori, N ;

Li, RH ;

Walsh, KA ;

Korstanje, R ;

Rollins, JA ;

Petkov, P ;

Pletcher, MT ;

Wiltshire, T ;

Donahue, LR ;

Rosen, CJ ;

Beamer, WG ;

Churchill, GA ;

Paigen, B .

JOURNAL OF BONE AND MINERAL RESEARCH, 2006, 21 (01) :105-112

[15] Quantitative trait loci on chromosomes 2p, 4p, and 13q influence bone mineral density of the forearm and hip in Mexican Americans [J].

Kammerer, CM ;

Schneider, JL ;

Cole, SA ;

Hixson, JE ;

Samollow, PB ;

O'Connell, JR ;

Perez, R ;

Dyer, TD ;

Almasy, L ;

Blangero, J ;

Bauer, RL ;

Mitchell, BD .

JOURNAL OF BONE AND MINERAL RESEARCH, 2003, 18 (12) :2245-2252

[16] Age, gender, and body mass effects on quantitative trait loci for bone mineral density: the Framingham Study [J].

Karasik, D ;

Cupples, LA ;

Hannan, MT ;

Kiel, DP .

BONE, 2003, 33 (03) :308-316

[17] Genome screen for quantitative trait loci contributing to normal variation in bone mineral density: The Framingham study [J].

Karasik, D ;

Myers, RH ;

Cupples, LA ;

Hannan, MT ;

Gagnon, DR ;

Herbert, A ;

Kiel, DP .

JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (09) :1718-1727

[18] Mapping quantitative trait loci that influence femoral cross-sectional area in mice [J].

Klein, RF ;

Turner, RJ ;

Skinner, LD ;

Vartanian, KA ;

Serang, M ;

Carlos, AS ;

Shea, M ;

Belknap, JK ;

Orwoll, ES .

JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (10) :1752-1760

[19] Quantitative trait loci affecting peak bone mineral density in mice [J].

Klein, RF ;

Mitchell, SR ;

Phillips, TJ ;

Belknap, JK ;

Orwoll, ES .

JOURNAL OF BONE AND MINERAL RESEARCH, 1998, 13 (11) :1648-1656

[20] Confirmation and fine mapping of chromosomal regions influencing peak bone mass in mice [J].

Klein, RF ;

Carlos, AS ;

Vartanian, KA ;

Chambers, VK ;

Turner, RJ ;

Phillips, TJ ;

Belknap, JK ;

Orwoll, ES .

JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (11) :1953-1961

← 1 2 3 4 5 →