Steamed Ginseng-Leaf Components Enhance Cytotoxic Effects on Human Leukemia HL-60 Cells

被引：41

作者：

Nguyen Huu Tung ^{[1
,2
]}

Song, Gyu Yong ^{[1
]}

Chau Van Minh ^{[2
]}

Phan Van Kiem ^{[2
]}

Jin, Long Guo ^{[1
]}

Boo, Hye-Jin ^{[3
]}

Kang, Hee-Kyoung ^{[3
]}

Kim, Young Ho ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Vietnam Acad Sci & Technol, Inst Nat Prod Chem, Hanoi 10000, Vietnam

[3] Jeju Natl Univ, Inst Med Sci, Sch Med, Dept Pharmacol, Cheju 690756, South Korea

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

Panax ginseng; Araliaceae; ginsenoside SL1; ginsenoside SL2; ginsenoside SL3; cytotoxicity; DAMMARANE; SAPONINS; LEAVES; GINSENOSIDES; GROWTH;

D O I：

10.1248/cpb.58.1111

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Three new dammarane-type glycosides, named ginsenosides SL1-SL3 (1-3), and eleven known compounds (4-14) were isolated from the heat-processed leaves of Panax ginseng. Their structures were elucidated on the basis of extensive chemical and spectroscopic methods. Cytotoxic-activity testing of compounds 1-14 against human leukemia HL-60 cells showed that ginsenosides Rh-3 (11) and Rk(2) (12) exhibited potent effects with IC50 values of 0.8 and 0.9 mu M. In addition, ginsenosides SL3 (3), 20S-Rg(2) (7), F-4 (10), 20S-Rh-2 (13) displayed strong activity with IC50 values of 9.0, 9.0, 7.5, and 8.2 mu M, respectively. This is the first report on chemical components of the steamed ginseng leaves.

引用

页码：1111 / 1115

页数：5

共 19 条

[1]

Azuma I., 1994, Ginseng Rev., V18, P37

[2]

Baek N, 1995, KOREAN J GINSENG SCI, V19, P45

[3]

Six new dammarane-type triterpene saponins from leaves of Panax ginseng [J].