Immunobiology of allogeneic hematopoietic stem cell transplantation

被引：381

作者：

Welniak, Lisbeth A. ^{[1
]}

Blazar, Bruce R.

Murphy, William J.

机构：

[1] Univ Nevada, Dept Microbiol & Immunol, Reno, NV 89557 USA

[2] Univ Minnesota, Ctr Canc, Minneapolis, MN 55455 USA

[3] Univ Minnesota, Dept Pediat, Div Blood & Marrow Transplantat, Minneapolis, MN 55455 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY | 2007年 / 25卷

关键词：

graft-versus-host disease; graft rejection; immune reconstitution;

D O I：

10.1146/annurev.immunol.25.022106.141606

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Allogeneic hematopoietic stem cell transplantation (HSCT) has evolved into an effective adoptive cellular immunotherapy for the treatment of a number of cancers. The immunobiology of allogeneic HSCT is unique in transplantation in that it involves potential immune recognition and attack between both donor and host. Much of the immunobiology of allogeneic HSCT has been gleaned from preclinical models and correlation with clinical observations. We review our current understanding of some of the issues that affect the success of this therapy, including host-versus-graft (HVG) reactions, graft-versus-host disease (GVHD), graft-versus-tumor (GVT) activity, and restoration of functional immunity to prevent transplant-related opportunistic infections. We also review new strategies to optimize the GVT and improve overall immune function while reducing GVHD and graft rejection.

引用

页码：139 / 170

页数：32

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