Direct Method for Carbon-Carbon Bond Formation: The Functional Group Tolerant Cobalt-Catalyzed Alkylation of Aryl Halides

被引：97

作者：

Amatore, Muriel ^{[1
]}

Gosmini, Corinne ^{[1
]}

机构：

[1] Ecole Polytech, CNRS, Lab Heteroelements & Coordinat, F-91128 Palaiseau, France

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 20期

关键词：

alkylation; cobalt; cross-coupling; homogeneous catalysis; synthetic methods; CROSS-COUPLING REACTIONS; GRIGNARD-REAGENTS; CONJUGATE ADDITION; ARYLATION; EFFICIENT; ACTIVATION; NITRILES; BROMIDES; BIARYLS; ACIDS;

D O I：

10.1002/chem.201000178

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented). A new protocol for the direct cobaltcatalyzed alkylation of aryl halides has been developed that proceeds smoothly in the presence of phosphanes or bipyridines as ligands with a variety of alkyl halides, including challenging alkyl electrophiles bearing β hydrogen atoms (see scheme). Sensitive functional groups are tolerated on both coupling partners, thus, significantly extending the general scope of transition-metal-catalyzed alkylation of aryl halides. © 2010 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5848 / 5852

页数：5

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