Running enhances spatial pattern separation in mice

被引：389

作者：

Creer, David J. ^{[1
]}

Romberg, Carola ^{[2
]}

Saksida, Lisa M. ^{[2
,3
,4
]}

van Praag, Henriette ^{[1
]}

Bussey, Timothy J. ^{[2
,3
,4
]}

机构：

[1] NIA, Neurosci Lab, Intramural Res Program, Baltimore, MD 21224 USA

[2] Univ Cambridge, Dept Expt Psychol, Cambridge CB2 3EB, England

[3] Univ Cambridge, MRC, Cambridge CB2 3EB, England

[4] Univ Cambridge, Wellcome Trust Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2010年 / 107卷 / 05期

基金：

美国国家卫生研究院;

关键词：

exercise; hippocampus; learning; neurogenesis; pattern separation; ADULT HIPPOCAMPAL NEUROGENESIS; DENTATE GYRUS; NMDA RECEPTORS; SYNAPTIC PLASTICITY; CELL-PROLIFERATION; PHYSICAL-ACTIVITY; GENE-EXPRESSION; IN-VIVO; MEMORY; EXERCISE;

D O I：

10.1073/pnas.0911725107

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Increasing evidence suggests that regular exercise improves brain health and promotes synaptic plasticity and hippocampal neurogenesis. Exercise improves learning, but specific mechanisms of information processing influenced by physical activity are unknown. Here, we report that voluntary running enhanced the ability of adult (3 months old) male C57BL/6 mice to discriminate between the locations of two adjacent identical stimuli. Improved spatial pattern separation in adult runners was tightly correlated with increased neurogenesis. In contrast, very aged (22 months old) mice had impaired spatial discrimination and low basal cell genesis that was refractory to running. These findings suggest that the addition of newly born neurons may bolster dentate gyrus-mediated encoding of fine spatial distinctions.

引用

页码：2367 / 2372

页数：6

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